ANTENATAL NUTRITIONAL SUPPLEMENTATION AND AUTISM SPECTRUM DISORDERS IN THE STOCKHOLM YOUTH COHORT: POPULATION BASED COHORT STUDY.
With the heritability of autism spectrum disorders (ASD) estimated to be between 50% and 80%, non-heritable risk factors contribute to a substantial proportion of ASD risk.
Research suggests that ASD develops antenatally. Maternal nutrition influences neurodevelopment and could influence the risk of ASD.
Objective of this rearch was to determine whether nutritional supplementation during pregnancy is associated with a reduced risk of autism spectrum disorder (ASD) with and without intellectual disability in offspring
We observed a potential inverse association between maternal multivitamin supplement use and ASD with intellectual disability in offspring. Whether the association is specific to autism or reflects the risk of intellectual disability needs to be explored in future research. Given the current understanding and strength of evidence supporting the importance of nutritional supplementation during pregnancy, these results on their own should not change current practice. Still, these findings raise questions that warrant investigation. A sufficient body of mechanistic evidence supporting the finding does not yet exist.
RESEARCH improved exposure assessment, perhaps in randomised studies, is necessary before recommending a change to current practice.